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Everyone has a donor: contribution of the Chinese experience to global practice of haploidentical hematopoieticstem cell transplantation

Meng Lv, Yingjun Chang, Xiaojun Huang

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 45-56 doi: 10.1007/s11684-017-0595-7

Abstract: Human leukocyte antigen (HLA)-matched donors for hematopoietic stem cell transplantation (HSCT) haveHaploidentical (haplo) donors are available for the vast majority of patients, but toxicity has limited

Keywords： haploidentical hematopoietic stem cell transplantation     conditioning     graft-versus-host disease     relapse    

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Positive stool culture could predict the clinical outcomes of haploidentical hematopoietic stem celltransplantation

Lijuan Hu, Qi Wang, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Kaiyan Liu, Hui Wang, Xiaojun Huang, Xiaodong Mo

Frontiers of Medicine 2019, Volume 13, Issue 4,   Pages 492-503 doi: 10.1007/s11684-019-0681-0

Abstract: identify the effect of positive stool cultures (PSCs) on the clinical outcomes of patients undergoing haploidenticalhematopoietic stem cell transplantation (haplo-HSCT) ( = 332).

Keywords： haploidentical     hematopoietic stem cell transplantation     stool culture     Candida    

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Lung transplantation for bronchiolitis obliterans syndrome after allogenic hematopoietic stem cell transplantation

Fei Gao, Jingyu Chen, Dong Wei, Bo Wu, Min Zhou

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 224-228 doi: 10.1007/s11684-017-0538-3

Abstract:

Bronchiolitis obliterans syndrome (BOS) after hematopoietic stem cell transplantation (HSCT) is aLung transplantation (LTX) has been rarely reported as a treatment option for selected HSCT recipients

Keywords： bronchiolitis obliterans syndrome (BOS)     hematopoietic stem cell transplantation (HSCT)     lung transplantation    

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Risk stratification system for skin and soft tissue infections after allogeneic hematopoietic stem celltransplantation: PAH risk score

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 957-968 doi: 10.1007/s11684-021-0910-1

Abstract: However, to date, the profiles and clinical outcomes of SSTIs in hematopoietic stem cell transplantation

Keywords： skin and soft tissue infections     hematopoietic stem cell transplantation     risk stratification system    

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Superiority of allogeneic hematopoietic stem cell transplantation to nilotinib and dasatinib for adult

Lanping Xu,Huanling Zhu,Jianda Hu,Depei Wu,Hao Jiang,Qian Jiang,Xiaojun Huang

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 304-311 doi: 10.1007/s11684-015-0400-4

Abstract: for patients with disease that progressed to accelerated phase following imatinib therapy, allogeneic hematopoieticstem cell transplantation (allo-HSCT) is the only curative therapy.(58.3%), and 3 (10%) patients underwent allo-HSCT from an HLA-matched sibling donor, HLA mismatched/haploidentical

Keywords： chronic myeloid leukemia     imatinib     dasatinib     nilotinib     allogeneic hematopoietic stem cell transplantation    

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Advancement of human leukocyte antigen-partially matched related hematopoietic stem cell transplantation

Xiaodong Mo, Xiaojun Huang

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 306-315 doi: 10.1007/s11684-013-0279-x

Abstract:

Allogeneic hematopoietic stem cell transplantation (HSCT) is one of the most effective options forSeveral protocols (with or without ex vivo T-cell depletion (TCD)) have been established worldwideassociated with prolonged immune deficiencies, increased risks of infectious complications, and high transplantation-related

Keywords： partially matched related donor     hematopoietic stem cell transplantation     allogeneic    

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Fludarabine and intravenous busulfan conditioning with post-transplantation cyclophosphamide for allogeneicperipheral stem cell transplantation for adult patients with lymphoid malignancies: a prospective single-arm

Ling Wang, Lining Wang, Xing Fan, Wei Tang, Jiong Hu

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 108-115 doi: 10.1007/s11684-019-0730-8

Abstract: Post-transplantation cyclophosphamide (PT-Cy) alone or in combination with other immunosuppressive drugshas emerged as a promising strategy in the setting of allogeneic hematopoietic stem cell transplantationcyclosporine as graft-versus-host disease (GVHD) prophylaxis after myeloablative conditioning and T cell-repleteperipheral stem cell transplantation in lymphoid malignancies.

Keywords： post-transplantation cyclophosphamide     allogeneic hematopoietic stem cell transplantation     lymphoid malignancies    

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Autologous peripheral hematopoietic stem-cell transplantation in a patient with refractory pemphigus

SUN Ledong, SUN Jing, ZENG Kang, MENG Fanyi, DIAO Youtao, XU Dan, HUANG Liang, ZHAO Jie, Liu Qifa

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 191-194 doi: 10.1007/s11684-008-0036-8

Abstract: The aim of this study is to explore the effectiveness of autologous peripheral hematopoietic stem-celltransplantation in the treatment of refractory pemphigus.Stem-cell mobilization was achieved by treatment with cyclophosphamide, granulocyte colony-stimulatingAutologous peripheral hematopoietic stem cell transplantation was followed by reconstitution of the immuneThe patient’s response suggests that autologous peripheral hematopoietic stem cell transplantation may

Keywords： serological activity     leukapheresis     peripheral hematopoietic     cyclophosphamide     resistance    

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Risk factors for chronic graft-versus-host disease after anti-thymocyte globulin-based haploidenticalhematopoietic stem cell transplantation in acute myeloid leukemia

Meng Lv, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang, Xiaodong Mo

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 667-679 doi: 10.1007/s11684-019-0702-z

Abstract: Chronic graft-versus-host disease (cGVHD) is a major complication following unmanipulated haploidenticalhematopoietic stem cell transplantation (haplo-HSCT).

Keywords： acute graft-versus-host disease     chronic graft-versus-host disease     National Institutes of Health consensus criteria     acute myeloid leukemia     anti-thymocyte globulin    

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Disease Risk Comorbidity Index for Patients Receiving Haploidentical Allogeneic Hematopoietic Transplantation Article

Xiao-Dong Mo, Xiao-Hui Zhang, Lan-Ping Xu, Yu Wang, Chen-Hua Yan, Huan Chen, Yu-Hong Chen, Wei Han, Feng-Rong Wang, Jing-Zhi Wang, Kai-Yan Liu, Xiao-Jun Huang

Engineering 2021, Volume 7, Issue 2,   Pages 162-169 doi: 10.1016/j.eng.2020.12.005

Abstract: p>We aimed to develop a disease risk comorbidity index (DRCI) based on disease risk index (DRI) and HematopoieticCell Transplantation-Specific Comorbidity Index (HCT-CI) in patients receiving haploidentical hematopoieticstem cell transplantation (haplo-HSCT).The multivariable model identified two independent predictors of DFS: DRI and HCT-CI before transplantation

Keywords： Disease risk index     Disease risk comorbidity index     Hematopoietic cell transplantation     comorbidity index     Hematopoietic stem cell transplantation     Haploidentical    

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Comparison of reference values for immune recovery between event-free patients receiving haploidentical

Xuying Pei, Xiangyu Zhao, Yu Wang, Lanping Xu, Xiaohui Zhang, Kaiyan Liu, Yingjun Chang, Xiaojun Huang

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 153-163 doi: 10.1007/s11684-017-0548-1

Abstract:

To establish optimal reference values for recovered immune cell subsets, we prospectively investigatedpost-transplant immune reconstitution (IR) in 144 patients who received allogeneic stem cell transplantationImmune recovery was generally faster under HLA-matched sibling donor transplantation than under haploidenticaltransplantation.that data from this recipient cohort should be used as reference values for post-transplant immune cell

Keywords： immune reconstitution     hematopoietic stem cell transplantation     event-free patients     reference range    

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In vivo imaging of hematopoietic stem cell development in the zebrafish

Panpan Zhang, Feng Liu

Frontiers of Medicine 2011, Volume 5, Issue 3,   Pages 239-247 doi: 10.1007/s11684-011-0123-0

Abstract: imaging is crucial for developmental biology and can further help to follow cell development/differentiationhas facilitated tracing of the developmental dynamics of a specific organ, tissue, or even a single cellimaging of hematopoiesis due to its transparent embryo at early stage; moreover, different zebrafish hematopoieticstem cells (HSCs) transgenic lines have been demonstrated as very useful tools for illustrating the

Keywords： hematopoietic stem cell     hematopoiesis     in vivo imaging     transgenics     zebrafish    

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Minimal residual disease-directed immunotherapy for high-risk myelodysplastic syndrome after allogeneic hematopoieticstem cell transplantation

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

Frontiers of Medicine 2019, Volume 13, Issue 3,   Pages 354-364 doi: 10.1007/s11684-018-0665-5

Abstract: investigated in patients with high-risk myelodysplastic syndrome (MDS) who were MRD-positive after allogeneic hematopoieticstem cell transplantation (allo-HSCT).High-risk MDS patients who received non-T-cell-depleted allo-HSCT at the Peking University Institute

Keywords： donor leukocyte infusion     hematopoietic stem cell transplantation     interferon-   

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Second unmanipulated allogeneic transplantation could be used as a salvage option for patients with relapsed

Frontiers of Medicine 2021, Volume 15, Issue 5,   Pages 728-739 doi: 10.1007/s11684-021-0833-x

Abstract: Relapse is the main problem after allogeneic hematopoietic stem cell transplantation (allo-HSCT).

Keywords： second hematopoietic stem cell transplantation     acute leukemia     relapse     chemotherapy     modified donor    

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Mutant DNA methylation regulators endow hematopoietic stem cells with the preleukemic stem cell property

Yuting Tan,Han Liu,Saijuan Chen

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 412-420 doi: 10.1007/s11684-015-0423-x

Abstract: mutations provides the first proof-of-principle investigation on the identification of preleukemic stemAlthough DNMT3A mutations alone may only transform hematopoietic stem cells into pre-LSCs without causing

Keywords： preleukemic stem cell     acute myeloid leukemia     relapse     DNMT3A    

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Title Author Date Type Operation

Everyone has a donor: contribution of the Chinese experience to global practice of haploidentical hematopoieticstem cell transplantation

Meng Lv, Yingjun Chang, Xiaojun Huang

Journal Article

Positive stool culture could predict the clinical outcomes of haploidentical hematopoietic stem celltransplantation

Lijuan Hu, Qi Wang, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Kaiyan Liu, Hui Wang, Xiaojun Huang, Xiaodong Mo

Journal Article

Lung transplantation for bronchiolitis obliterans syndrome after allogenic hematopoietic stem cell transplantation

Fei Gao, Jingyu Chen, Dong Wei, Bo Wu, Min Zhou

Journal Article

Risk stratification system for skin and soft tissue infections after allogeneic hematopoietic stem celltransplantation: PAH risk score

Journal Article

Superiority of allogeneic hematopoietic stem cell transplantation to nilotinib and dasatinib for adult

Lanping Xu,Huanling Zhu,Jianda Hu,Depei Wu,Hao Jiang,Qian Jiang,Xiaojun Huang

Journal Article

Advancement of human leukocyte antigen-partially matched related hematopoietic stem cell transplantation

Xiaodong Mo, Xiaojun Huang

Journal Article

Fludarabine and intravenous busulfan conditioning with post-transplantation cyclophosphamide for allogeneicperipheral stem cell transplantation for adult patients with lymphoid malignancies: a prospective single-arm

Ling Wang, Lining Wang, Xing Fan, Wei Tang, Jiong Hu

Journal Article

Autologous peripheral hematopoietic stem-cell transplantation in a patient with refractory pemphigus

SUN Ledong, SUN Jing, ZENG Kang, MENG Fanyi, DIAO Youtao, XU Dan, HUANG Liang, ZHAO Jie, Liu Qifa

Journal Article

Risk factors for chronic graft-versus-host disease after anti-thymocyte globulin-based haploidenticalhematopoietic stem cell transplantation in acute myeloid leukemia

Meng Lv, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang, Xiaodong Mo

Journal Article

Disease Risk Comorbidity Index for Patients Receiving Haploidentical Allogeneic Hematopoietic Transplantation

Xiao-Dong Mo, Xiao-Hui Zhang, Lan-Ping Xu, Yu Wang, Chen-Hua Yan, Huan Chen, Yu-Hong Chen, Wei Han, Feng-Rong Wang, Jing-Zhi Wang, Kai-Yan Liu, Xiao-Jun Huang

Journal Article

Comparison of reference values for immune recovery between event-free patients receiving haploidentical

Xuying Pei, Xiangyu Zhao, Yu Wang, Lanping Xu, Xiaohui Zhang, Kaiyan Liu, Yingjun Chang, Xiaojun Huang

Journal Article

In vivo imaging of hematopoietic stem cell development in the zebrafish

Panpan Zhang, Feng Liu

Journal Article

Minimal residual disease-directed immunotherapy for high-risk myelodysplastic syndrome after allogeneic hematopoieticstem cell transplantation

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

Journal Article

Second unmanipulated allogeneic transplantation could be used as a salvage option for patients with relapsed

Journal Article

Mutant DNA methylation regulators endow hematopoietic stem cells with the preleukemic stem cell property

Yuting Tan,Han Liu,Saijuan Chen

Journal Article